Gut Microbes and ALS
TWiM explains the connection between inflammation caused by microbial glycogen in the gut and amyotrophic lateral sclerosis, and how disruption of cysteine metabolism leads to synthetic lethality and in vivo fitness impa...
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Vincent Racaniello
TWiM explains the connection between inflammation caused by microbial glycogen in the gut and amyotrophic lateral sclerosis, and how disruption of cysteine metabolism leads to synthetic lethality and in vivo fitness impa...
TWiM visits Tufts University School of Medcine and are joined by John Coffin, Michael Malamy, and Verna Manni for a tribute to Elio Schaechter who was chair of Molecular Biology and Microbiology for 23 years. Hosts: Vinc...
TWiM explains how Streptococcus mitis bacteriocins drive contact-dependent lysis of S. pneumoniae facilitating transformation, and microbial dominance in diabetic foot osteomyelitis determined with nanopore sequencing. H...
TWiM explains how an enhanced domestication method allows for growth of uncultured bacteria, and identification of the oncogene SLC35F2 as is a high-specificity transporter for the micronutrients queuine and queuosine. H...
TWiM explains a candidate signature of health in the gut microbial community, and how an intestinal bacterium exacerbates cardiac ischemia/reperfusion injury. Hosts: Vincent Racaniello, Michael Schmidt, Michele Swanson a...
TWiM explains how to use microbes to enhance maize yield and reduce corn rootworm damage, and how the human microbiota modulates IgE-mediated reactions to foods through allergen metabolism. Hosts: Michael Schmidt, Petra ...
TWiM reveals the archaeal roots of eukaryotic life, and a building a gut malabsorption biosensor with bacteria. Become a patron of TWiM. Music used on TWiM is composed and performed by Ronald Jenkees and used with permis...
TWiM discusses the use of bacteriophage-loaded microneedle patches for targeted and minimally disruptive foodborne pathogen decontamination, and a conjugal gene drive-like system that efficiently suppresses antibiotic re...
Nancy and Maggie join TWiM to share how and why they created a freely available ebook of TWiM-based science literacy resources and classroom exercises that support teaching across key microbiology and molecular biology t...
TWiM explains how mechano-bactericidal surfaces made from diverse materials and patterned with spikes kill bacteria on contact, and virus-host evolution is reshaped by microgravity aboard the International Space Station....
TWiM explains the finding that owning a dog during adolescence alters the microbiota and improves mental health, and the molecular basis for multidrug efflux by an anaerobic-associated resistance-nodulation-cell division...
TWiM explains how S. aureus pathogenicity is a dynamic, niche-specific choreography that constantly recalibrates in response to the host microenvironment, and short chain fatty acids produced by commensal microbiota redu...
TWiM explains how competition for nutrients anticipates and potentially mitigate drug side effects on the gut microbiota, and metabolic control of porin permeability influences antibiotic resistance. Hosts: Vincent Raca...
TWiM explains a biological mechanism that links sulfur and iron cycling in anoxic environments, and "swashing," a form of surface movement in which bacteria migrate without active propulsion. Hosts: Michael Schmidt, Mic...
TWiM reveals the bacteria, acids, and enzymes behind yogurt made with ants, and a defined set of microbes that reproduces attributes of fine flavor chocolate fermentation Hosts: Vincent Racaniello, Michael Schmidt, ...
TWiM explores two different ways that bacteria defend against phages through the synthesis of cyclic nucleotides. Hosts: Michael Schmidt and Mark O. Martin Become a patron of TWiM. Links for this episode: Dec...
TWiM explains studies that show that the oral bacterial and fungal microbiome are risk factors for pancreatic cancer, and the gut microbiome and pyruvate metabolism of older adults are a link between sleep quality and fr...
TWiM reveals a Vibrio as the causative agent of sea star wasting disease, and using microcolony-seq to uncover phenotypic inheritance from single cells. Hosts: Michael Schmidt and Michele Swanson Guest: Mark O. Marti...
TWiM explores the varied and distinct microbiome of trees, and an array of biopesticidal metabolites against mosquito larvae isolated from a Mediterranean island. Become a patron of TWiM. Links for this episode:
TWiM pays tribute to Elio Schaechter, former TWiM host, blogger, and microbiologist extraordinaire, then reviews the finding that Archaea produce peptidoglycan hydrolases that kill bacteria - a form of competition. Hosts...
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