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The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 minus The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 minus BZ Group Space Croutons Space Croutons Goodwich Audio Productions Talking Pools Podcast Talking Pools Podcast Rudy Stankowitz The Real Truth About Health Free 17 Day Live Online Conference Podcast The Real Truth About Health Free 17 Day Live Online Conference Podcast Lloyd Burrell, Keith Block M.D., Jeffrey Smith, Michael Klaper M.D., Ralph Moss, Brenda Davis R.D., Mark Sloan, Gerald Posner, Ian Harris M.D., Neil Barnard M.D., Will Tuttle Ph.D., John McDougall M.D., Pam Popper Ph.D., Gabriel Cousens M.D., Brian Clement Ph.D., Anna Maria Clement Ph.D., Marianne Williamson, Vandana Shiva Ph.D., Aly Cohen M.D., Milton Mills M.D., Theodora Scarato, William Li M.D., David Katz M.D., Stephanie Seneff Ph.D., Julieanna Hever M.S., Dale Bredesen M.D., Hope Bohanec, Kim Williams M.D., Joel Kahn M.D., Michelle Perro M.D., David Wolfe, Melanie Joy Ph.D., Sunil Pai M.D., Baxter Montgomery M.D., Michael Greger M.D., Caldwell Esselstyn M.D., Joel Fuhrman M.D., Colin Campbell Ph.D. Huberman Lab Huberman Lab Huberman Lab From Fact To Fiction: Thrilling Book Reviews From Fact To Fiction: Thrilling Book Reviews From Fact To Fiction with Author L M Whitaker 老梁说法|资深媒体人带你法眼看世界 老梁说法|资深媒体人带你法眼看世界 老梁不郁闷 Travelling Light Travelling Light Monstrous Productions 🎙️ Science News Daily | Peer Review'd 🎙️ Science News Daily | Peer Review'd Peer Review'd On This Day in Working Class History On This Day in Working Class History Working Class History The Sadhguru Podcast - Of Mystics and Mistakes The Sadhguru Podcast - Of Mystics and Mistakes Sadhguru Official Ça Se Passe Là-Haut Ça Se Passe Là-Haut Eric Simon The Messed Up Gardener The Messed Up Gardener Esther William (Aitken) Heliox: Where Evidence Meets Empathy 🇨🇦‬ Heliox: Where Evidence Meets Empathy 🇨🇦‬ by SC Zoomers 天方烨谈 天方烨谈 基因频道 TheThinkingAtheist TheThinkingAtheist The Thinking Atheist The Sheep Show Podcast with Jill & Andrew Noble The Sheep Show Podcast with Jill & Andrew Noble Jill Noble American Roots Outdoors w/ Alex Rutledge American Roots Outdoors w/ Alex Rutledge American Roots Outdoors w/ Alex Rutledge ВИВАТ, ИСТОРИЯ! ВИВАТ, ИСТОРИЯ! MOTORADIO.ONLINE Earth Ancients Earth Ancients Cliff Dunning Arroe Collins Forest Stories Arroe Collins Forest Stories Arroe Collins Gardening Simplified Gardening Simplified Newsradio WOOD 1300 and 106.9 FM (WOOD-AM) ToKCast ToKCast Brett Hall Jack's Backyard Jack's Backyard 830 WEEU "The Voice of Berks and Beyond" My Weird Prompts My Weird Prompts Daniel Rosehill Fox Weather Update Fox Weather Update Fox Weather Eye On The Sky Eye On The Sky Vermont Public 艾灸养生108招 |病来了,不用怕 艾灸养生108招 |病来了,不用怕 冯名雨艾灸 IS PHARMACOLOGY DIFFICULT®️ Podcast IS PHARMACOLOGY DIFFICULT®️ Podcast Dr Radhika Vijay Cose Molto Umane di Gianpiero Kesten Cose Molto Umane di Gianpiero Kesten Gianpiero Kesten - Vois Dead America - Zombie Audiobook Series Dead America - Zombie Audiobook Series DerekSlatonAuthor Seventy3 Seventy3 任雨山 Accès au Marché Mondial des Dispositifs Médicaux Accès au Marché Mondial des Dispositifs Médicaux Pure Global Глобальный доступ на рынок медицинских изделий Глобальный доступ на рынок медицинских изделий Pure Global चिकित्सा उपकरण वैश्विक बाजार पहुंच चिकित्सा उपकरण वैश्विक बाजार पहुंच Pure Global Tıbbi Cihazlar Küresel Pazar Erişimi Tıbbi Cihazlar Küresel Pazar Erişimi Pure Global Akses Pasar Global Alat Kesehatan Akses Pasar Global Alat Kesehatan Pure Global
The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 minus

Science

The Pharma Closeout | Daily Pharmaceutical & Biotech News in 15 minus

BZ Group

Enbrel Price Cap Blocked: One Ruling That Could Reshape States Drug Pricing

July 03, 2026 7:22pm 9 min

Federal court blocks Colorado's 70% price cap on Enbrel — ruling could shut down state drug pricing laws nationwide. Plus: Casgevy label expansion to age 2 for SCD/TDT sends CRISPR Therapeutics surging 8%. Moderna mFLUSI...

Roche Divarasib Beats Both KRAS G12C Rivals in Phase 3 Lung Cancer Study

July 03, 2026 7:22pm 10 min

Roche's divarasib beats both KRAS G12C rivals on PFS and OS in head-to-head Phase 3, hitting survival significance at interim. AstraZeneca returns to CSPC in a $1.7B siRNA kidney disease deal; Abivax surges on $920M rais...

July 01, 2026| Tregzi Approved — Orca Bio Opens a New Lane in Cell Therapy

July 01, 2026 8:11pm 10 min

FDA approves Orca Bio's Tregzi — the first precision-engineered cell therapy for allogeneic transplant, sparking IPO speculation. Plus BridgeBio secures $1B from Sixth Street and KKR at a 100%+ conversion premium, Ipsen'...

Jun 30, 2026 | NEJM Retracts Tavneos Pivotal Trial; Ionis Tryngolza PDUFA Today

June 30, 2026 11:38pm 10 min

NEJM retracts Amgen's ADVOCATE study after FDA findsendpoint data for 9 patients re-evaluated post-unblinding. Plus: Ionis faces the Tryngolza sNDA PDUFA in severe hypertriglyceridemia, AbbVie's Epkinly delivers chemo-fr...

Jun 29, 2026 | Orforglipron PDUFA Tomorrow: Lilly Trades Above Consensus

June 29, 2026 9:47pm 14 min

Lilly at $1,230 — trading above analyst consensus — as orforglipron faces its FDA verdict tomorrow. Three label items to watch beyond the headline, plus healthcare's dramatic sub-sector bifurcation: drug makers up 25% YT...

Jun 26, 2026 | FDA Approves Viridian for Thyroid Eye Disease; Merck KGaA's $11.3B Bio-Techne Deal

June 27, 2026 5:50pm 14 min

FDA breaks Amgen's Tepezza monopoly with Viridian's Lumvoa approval in thyroid eye disease. Plus Merck KGaA's $11.3B Bio-Techne acquisition, Biogen gutting the Apellis pipeline post-$5.6B deal, CHMP moves to revoke Tavne...

Jun 25, 2026 | Ionis Tryngolza FDA Label Expansion Hits Commercial Inflection

June 26, 2026 2:14am 9 min

FDA approves Ionis Tryngolza as first treatment to reduce pancreatitis risk in severe hypertriglyceridemia — a potential blockbuster expansion. Merck KGaA acquires Bio-Techne for $11.3B in largest deal in a decade. SCOTU...

Jun 24, 2026 | FDA Approves Gilead's Trodelvy for Front-Line TNBC; Lilly's $1.9B Abbisko Deal

June 25, 2026 12:04am 13 min

Gilead's Trodelvy wins front-line triple-negative breast cancer approval — and the stock barely moves. Lilly expands its Abbisko partnership to $1.9B, Novartis pays $105M upfront to Antares for undruggable cancer targets...

Jun 23, 2026 | Pfizer Seagen ADC Fails in Lung Cancer Phase 3; CMS Settles Opzelura Classification

June 23, 2026 9:19pm 14 min

Pfizer's sigvotatug vedotin disappoints in Phase 3 NSCLC — another blow to the $43B Seagen deal. Plus CMS settles with Incyte on Opzelura classification, Sangamo Therapeutics closes after 30 years, and Moderna's flu vacc...

Jun 22, 2026 | AbbVie's $10.9B Apogee Buy Targets Dupixent; 1st Solid Tumor CAR-T Approved in China

June 22, 2026 9:18pm 10 min

AbbVie bets $10.9B on Apogee Therapeutics to challenge Dupixent — its biggest deal since Allergan. Plus: the first CAR-T approved for a solid tumor clears in China, Merck's $10.8B Prometheus IBD bet pays off with a Phase...

Jun 19, 2026 | US Probes Germany Drug Pricing; Moderna Flu Vaccine Wins Unanimous FDA Panel

June 20, 2026 2:01am 10 min

US government opens formal probe into Germany's drug pricing reforms, escalating transatlantic pharma trade tensions. Kardigan IPO raises $400M and pops 31%. Moderna flu vaccine gets unanimous FDA advisory panel support ...

Jun 18, 2026 | Moderna mFlusiva Wins Unanimous VRBPAC Vote; NovoCure TRIDENT Fails in GBM

June 18, 2026 8:50pm 13 min

Moderna's mRNA flu vaccine gets unanimous FDA panel backing — PDUFA August 5. NovoCure's TRIDENT trial misses overall survival in glioblastoma; stock drops ~18%. Biogen acquires immunology startup RayThera for up to $1B;...

Jun 17, 2026 | UniQure AMT-130 Surges 70% on FDA Reversal; Jazz-AbCellera $4.1B TCE Deal

June 17, 2026 9:17pm 14 min

UniQure surges 70% as FDA reverses course on Huntington's gene therapy AMT-130 filing path. Jazz and AbCellera strike $4.1B T cell engager deal for GI cancers. Novo Nordisk faces $25M ransom demand after hackers claim dr...

Jun 16, 2026 | BridgeBio BBP-418 Sweeps LGMD Phase 3; FDA Scrutinizes Moderna Flu Vaccine

June 17, 2026 7:30am 10 min

BridgeBio's BBP-418 sweeps Phase 3 in limb-girdle muscular dystrophy — stock up 15%, no approved competition. FDA briefing docs challenge Moderna mFlusiva efficacy ahead of Thursday's VRBPAC vote. Plus Lilly acquires non...

Jun 15, 2026 | CMS Targets SubQ Keytruda and Opdivo Loophole; Takeda Beats Sotyktu Head-to-Head

June 15, 2026 11:24pm 10 min

CMS proposes closing Medicare negotiation loophole threatening Keytruda and Opdivo subcutaneous strategies — billions at stake. Plus Takeda's zasocitinib tops Sotyktu, Novartis validates $12B Avidity deal, Elicio's KRAS ...

EHA 2026 Special — Full Meeting Recap

June 14, 2026 11:59pm 20 min

The Pharma Closeout's comprehensive recap of EHA 2026(Stockholm, June 11-14). HEADLINE: J&J's MonumenTAL-3 (talquetamab +daratumumab) in earlier-line R/R myeloma — PFS HR 0.28/0.33, complete-response 71% vs 34.5%, NEJM-p...

Jun 12, 2026 | FDA Approves Merck Welireg-Keytruda for Kidney Cancer; Jazz Zepzelca Phase 3 Fails

June 12, 2026 10:29pm 13 min

FDA approves Merck's Welireg-Keytruda combo for adjuvant kidney cancer — 28% risk reduction vs. active Keytruda monotherapy in LITESPARK-022. Jazz's Zepzelca misses OS endpoint in Phase 3 LAGOON, Incyte acquires Vega The...

Jun 11, 2026 | Takeda Zasocitinib Beats Sotyktu in Head-to-Head Phase 3; Summit Pulls $500M Offering

June 12, 2026 9:22am 10 min

Zasocitinib hits 35% complete skin clearance at week 16,topping Sotyktu by more than 2.5x in Takeda's head-to-head Phase 3. Plus: Novartis validates its $12B Avidity AOC platform in FSHD, Summit withdraws $500M offering,...

Jun 10, 2026 | Parabilis Sets Record $670M Biotech IPO; Sanofi Halts Riliprubart Phase 3

June 11, 2026 4:20pm 9 min

Parabilis Medicines prices the largest-ever venture-backed biotech IPO at $670M as 12 startups top $4.1B in 2026. Sanofi stops MOBILIZE Phase 3 for riliprubart in CIDP. TG Therapeutics surges on Briumvi myasthenia gravis...

ADA 2026 Special: The full recap

June 11, 2026 4:19pm 25 min

The Pharma Closeout's full recap of the American Diabetes Association's 86th Scientific Sessions (New Orleans,June 5-8, 2026) - the meeting that ended the A1C-only era and reset what obesity medicine can do. Hosts Alex M...

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